Uncovering biological mechanisms through the intersection of mechanistic modeling and scalable algorithms.
Our lab develops predictive models of cell metabolism, protein expression, and gene regulation. These models integrate multiple biological processes and large-scale networks. Interpreting biological data in the context of these integrated models provides a systems-level perspective on cellular functions. Application areas include microbial production of chemicals, infectious disease, and human diseases linked to nutritional deficiencies or distinct metabolic shifts.